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PublicationsLisi V, Major F. 2007. A comparative analysis of the triloops in all high-resolution RNA structures reveals sequence-structure relationships. RNA.Lisi V, Major F. 2007. Discovering Auto-Regulatory Feed-Back Loops Involving micro RNAs and Transcription Factors in Cancer Development. miRNA and Cancer Keystone Symposium. Keystone, Colorado, USA. Lisi V, Major F. 2007. A Comparative Analysis of the Triloops in all High-Resolution RNA Structures Reveals Sequence-Structure Relationships. RiboClub 2007 Opening Session. Cheribourg, Canada. Parisien M, Lisi V, Major F. 2007. MC-Fold: A Novel RNA Folding Approach Based On Nucleotide Cyclic Motifs And Its Application To RNAi. RiboClub 2007 Opening Session. Cheribourg, Canada.
I started my Ph.D in September 2006 and already, I have some interesting results. I am currently working on the discovery of auto-regulatory feedback loops involvind miRNAs and transcription factors (TF). I combine the information in databases on miRNA and TF, extracting the miRNA/TF pairs where the miRNA inhibits the TF where the TF stimulates the miRNA.I found over 200 of these regulatory loops and will be experimentally validating some of those, hopefully soon.
I presented this work at the miRNA and Cancer Keystone Symposium in a poster.
For my master's, I worked on the RNA triloop motif. I was able to show the dynamics of the triloop motif using the X-ray crystal structures available in the PDB database and, most importantly, that the details of the structure of a triloop can be predicted from its flanking base pair. The manuscript has now been accepted.
I did my B.Sc at McGill University in Computer Science where I worked on the graphical user interface design, using statecharts, of a meta-modelling tool. A summary of my project is available here
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